PittsburghV1, Main, Exploration, bibRecord, 001374

Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women

Identifieur interne : 001374 ( Main/Exploration ); précédent : 001373; suivant : 001375

Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women

Auteurs : Vanessa W. Lim [Singapour] ; Jun Li [Singapour] ; Yinhan Gong [Singapour] ; Aizhen Jin [Singapour] ; Jian-Min Yuan [États-Unis] ; Eu Leong Yong [Singapour] ; Woon-Puay Koh [Singapour]

Source :

Endocrine-related cancer [ 1351-0088 ] ; 2014.

RBID : PMC:3962747

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Cellules HeLa, Femelle, Globuline de liaison aux hormones sexuelles (métabolisme), Humains, Oestradiol (sang), Oestrone (sang), Post-ménopause (sang), Risque, Récepteur alpha des oestrogènes (métabolisme), Récepteur bêta des oestrogènes (métabolisme), Singapour (épidémiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (métabolisme), Tumeurs du sein (sang), Études cas-témoins.
MESH :
- métabolisme : Globuline de liaison aux hormones sexuelles, Récepteur alpha des oestrogènes, Récepteur bêta des oestrogènes, Tumeurs du sein.
- sang : Oestradiol, Oestrone, Post-ménopause, Tumeurs du sein.
- épidémiologie : Singapour.
- Adulte d'âge moyen, Cellules HeLa, Femelle, Humains, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
Wicri :
- geographic : Singapour.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Breast Neoplasms (blood), Breast Neoplasms (metabolism), Case-Control Studies, Estradiol (blood), Estrogen Receptor alpha (metabolism), Estrogen Receptor beta (metabolism), Estrone (blood), Female, HeLa Cells, Humans, Middle Aged, Postmenopause (blood), Risk, Sex Hormone-Binding Globulin (metabolism), Singapore (epidemiology).
MESH :
- chemical , blood : Estradiol, Estrone.
- geographic , epidemiology : Singapore.
- blood : Breast Neoplasms, Postmenopause.
- metabolism : Breast Neoplasms, Estrogen Receptor alpha, Estrogen Receptor beta, Sex Hormone-Binding Globulin.
- Aged, Aged, 80 and over, Case-Control Studies, Female, HeLa Cells, Humans, Middle Aged, Risk.

Abstract

The estrogen levels of Asian women are different from those of Western women, and this could affect estrogen receptor (ER) bioactivity and breast cancer risk. We conducted a case-control study of 169 postmenopausal breast cancer cases and 426 matched controls nested within a population-based prospective cohort, The Singapore Chinese Health Study, to evaluate serum levels of estrogens and their receptor (ERα and ERβ)-mediated estrogenic activities in relation to breast cancer risk. Breast cancer cases had higher levels of estrogens and estrogen receptor mediated bioactivities in baseline serum than controls. Compared to the lowest quartile, women in the highest quartile for estrone or ERα-mediated bioactivity had increased breast cancer risk. After additional adjustment for ERβ bioactivity, free E2 and estrone; serum ERα-mediated estrogenic activity remained associated with increased breast cancer risk. Compared to the lowest quartile, women in the highest quartile for ERα-mediated bioactivity had an odds ratio of 2.39 (95% confidence interval=1.17–4.88, p for trend=0.016). Conversely, the positive association between estrone and cancer risk became null after adjustment for ERα-mediated estrogenic activity, suggesting that the effect of estrone could be mediated through ERα. Identification of the factor(s) contributing to increased ERα-mediated estrogenic bioactivity in sera, and its role as a predictor for breast cancer risk needs to be validated in future studies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962747

DOI: 10.1530/ERC-13-0233
PubMed: 24322303
PubMed Central: 3962747

Affiliations:

Le document en format XML

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<term>Breast Neoplasms (blood)</term>
<term>Breast Neoplasms (metabolism)</term>
<term>Case-Control Studies</term>
<term>Estradiol (blood)</term>
<term>Estrogen Receptor alpha (metabolism)</term>
<term>Estrogen Receptor beta (metabolism)</term>
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<term>HeLa Cells</term>
<term>Humans</term>
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<term>Sex Hormone-Binding Globulin (metabolism)</term>
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<term>Humains</term>
<term>Oestradiol (sang)</term>
<term>Oestrone (sang)</term>
<term>Post-ménopause (sang)</term>
<term>Risque</term>
<term>Récepteur alpha des oestrogènes (métabolisme)</term>
<term>Récepteur bêta des oestrogènes (métabolisme)</term>
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<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du sein (métabolisme)</term>
<term>Tumeurs du sein (sang)</term>
<term>Études cas-témoins</term>
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<term>Estrogen Receptor alpha</term>
<term>Estrogen Receptor beta</term>
<term>Sex Hormone-Binding Globulin</term>
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<term>Récepteur bêta des oestrogènes</term>
<term>Tumeurs du sein</term>
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<term>Post-ménopause</term>
<term>Tumeurs du sein</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">The estrogen levels of Asian women are different from those of Western women, and this could affect estrogen receptor (ER) bioactivity and breast cancer risk. We conducted a case-control study of 169 postmenopausal breast cancer cases and 426 matched controls nested within a population-based prospective cohort, The Singapore Chinese Health Study, to evaluate serum levels of estrogens and their receptor (ERα and ERβ)-mediated estrogenic activities in relation to breast cancer risk. Breast cancer cases had higher levels of estrogens and estrogen receptor mediated bioactivities in baseline serum than controls. Compared to the lowest quartile, women in the highest quartile for estrone or ERα-mediated bioactivity had increased breast cancer risk. After additional adjustment for ERβ bioactivity, free E2 and estrone; serum ERα-mediated estrogenic activity remained associated with increased breast cancer risk. Compared to the lowest quartile, women in the highest quartile for ERα-mediated bioactivity had an odds ratio of 2.39 (95% confidence interval=1.17–4.88, p for trend=0.016). Conversely, the positive association between estrone and cancer risk became null after adjustment for ERα-mediated estrogenic activity, suggesting that the effect of estrone could be mediated through ERα. Identification of the factor(s) contributing to increased ERα-mediated estrogenic bioactivity in sera, and its role as a predictor for breast cancer risk needs to be validated in future studies.</p>
</div>
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<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
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Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women

Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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